Spatial and temporal patterns and factors influencing the spread of the COVID-19 pandemic in China

It is essential to unravel the spatial and temporal patterns of the spread of the epidemic in China during the backdrop of the global coronavirus disease 2019 (COVID-19) outbreak in 2020, as the underlying drivers are crucial for scientific formulation of epidemy-preventing strategies. A discriminant model for the spatio-temporal pattern of epidemic spread was developed for 317 prefecture-level cities using accumulated data on confirmed cases. The model was introduced for the real-time evolution of the outbreak starting from the rapid spread of COVID-19 on January 24, 2020, until the control on March 18, 2020. The model was used to analyze the basic characteristics of the spatio-temporal patterns of the epidemic spread by combining parameters such as peak position, full width at half maximum, kurtosis, and skewness. A multivariate logistic regression model was developed to unravel the key drivers of the spatio-temporal patterns based on traffic accessibility, urban connectivity, and population flow. The results of the study are as follows. (1) The straight-line distance of 588 km from Wuhan was used as the effective boundary to identify the four spatial patterns of epidemic spread, and 13 types of spatio-temporal patterns were obtained by combining the time-course categories of the same spatial pattern. (2) The spread of the epidemic was relatively severe in the leapfrogging model. Besides the short-distance leapfrogging model, significant differences emerged in the spatial patterns of the time course of epidemic spread. The peaks of the new confirmed cases in various spatio-temporal patterns were mostly observed on February 3, 2020. The average full widths at the half maximum of all ordinary cities were approximately 14 days, thus, resonating with the incubation period of the COVID-19 virus. (3) The degree of the population correlation with Wuhan city has mainly influenced the spreading and the short-distance leapfrogging spatial patterns. The existence of direct flight from Wuhan city exhibited a positive effect on the long-distance leapfrogging spatial pattern. The number of population outflows has significantly affected the leapfrogging spatial pattern. The integrated spatial pattern was influenced by both primary and secondary epidemic outbreak sites. Thus, cities should pay great attention to traffic control during the epidemic as analysis has shown that the spatio-temporal patterns of epidemic spread in the respective cities can curb the spread of the epidemic from key links. © 2022, Science Press. All right reserved.

Hemoadsorption cartridge and coronavirus disease 2019 infections: A case report and brief literature review.

The cytokine storm has been frequently reported to occur in patients with severe coronavirus disease 2019 (COVID-19). Data from the literature suggest that elevated levels of inflammatory mediators, such as interleukin (IL)-6, IL-8, and tumor necrosis factor, indicate a severe course or the fatality of the disease. Several therapeutic options have been employed to treat critically ill patients, including hemoadsorption of inflammatory mediators. We here present a case of severe acute respiratory syndrome caused by COVID-19 and acute renal failure. The patient was admitted to our intensive care unit and treated with mechanical ventilation, renal replacement therapy, and hemoadsorption to reduce the cytokine release syndrome, which plays a fundamental role in the clinical presentation of COVID-19 patients. We also discuss the potential advantages of reducing cytokine plasma levels using a hemoadsorption cartridge.

Impact of the COVID-19 pandemic on the Colombian population according to mitigation measures Preliminary data from epidemiological models for the period March 18 to April 18, 2020

Introduction First case of COVID-19 in Colombia was diagnosed on March 6th. Two weeks later, cases have rapidly increased, leading the government to establish some mitigation measures. Objectives The first objective is to estimate and model the number of cases, use of hospital resources and mortality by using different R0 scenarios in a 1-month scenario (from March 18 to April 18, 2020), based on the different isolation measures applied. This work also aims to model, without establishing a time horizon, the same outcomes given the assumption that eventually 70% of the population will be infected. Materials and Methods Data on the number of confirmed cases in the country as of March 18, 2020 (n=93) were taken as the basis for the achievement of the first objective. An initial transmission rate of R0= 2.5 and a factor of 27 for undetected infections per each confirmed case were taken as assumptions for the model. The proportion of patients who may need intensive care or other in-hospital care was based on data from the Imperial College of London. On the other hand, an age-specific mortality rate provided by the Instituto Superiore di Sanità in Italy was used for the second objective. Results Based on the 93 cases reported as of March 18, if no mitigation measures were applied, by April 18, the country would have 613 037 cases. Mitigation measures that reduce R0 by 10% generate a 50% reduction in the number of cases. However, despite halving the number of cases, there would still be a shortfall in the number of beds required and only one in two patients would have access to this resource. Conclusion This model found that the mitigation measures implemented to date by the Colombian government and analyzed in this article are based on sufficient evidence and will help to slow the spread of SARS-CoV-2 in Colombia. Although a time horizon of one month was used for this model, it is plausible to believe that, if the current measures are sustained, the mitigation effect will also be sustained over time. © 2020, Universidad Nacional de Colombia. All rights reserved.